Active Pharmaceutical Ingredients (APIs) are the critical components in drug formulations, requiring precise particle size distribution to achieve consistent potency, dissolution rates, and bioavailability. The pharmaceutical industry enforces strict quality control standards, making efficient sieving essential for achieving uniform API particle sizes while preventing contamination and product loss.
However, traditional vibratory sieving machines and/or ultrasonic sieving machines often struggle with screen mesh blinding or clogging, electrostatic buildup, and inconsistent separations when handling ultra-fine API powders. Elcan Industries’ high energy sieving machine provides a GMP solution, enabling efficient and precise classification of APIs down to ultra-fine sizes without compromising product purity.
Processing active pharmaceutical ingredients requires precision, contamination control, and regulatory compliance. The Hi-Sifter is designed to exceed industry expectations by providing high-purity API powders with consistent particle size distribution. Traditional screening methods can introduce inefficiencies such as material degradation, inconsistent separations, and high product losses, but Elcan’s high energy technology eliminates these concerns.
By utilizing advanced vibratory screening, the Hi-Sifter prevents agglomeration and delivers high throughput rates, making it ideal for pharmaceutical manufacturers and contract API processors. The machine’s ability to prevent mesh blinding is particularly beneficial when working with fine, cohesive, or electrostatic API powders. This results in enhanced powder flowability, supporting smooth downstream processing for tablet pressing, encapsulation, and formulation blending.
With growing regulatory oversight in pharmaceutical manufacturing, maintaining compliance with Good Manufacturing Practices (GMP) is essential. Elcan’s sieving solutions are available in pharmaceutical-grade 316 stainless steel construction and are designed to meet FDA, cGMP, and cleanroom requirements.
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