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What Are Excipients? Pharmaceutical excipients are inactive ingredients used in drug formulations to support the delivery, stability, manufacturability, and absorption of the active pharmaceutical ingredient (API). These substances—such as microcrystalline cellulose (MCC), maltitol, lactose, starches, magnesium stearate, and silicon dioxide—play critical roles in ensuring tablets and capsules meet strict performance, shelf-life, and safety standards. Although they don’t contribute directly to therapeutic effects, excipients can significantly affect drug solubility, disintegration, flow, and patient experience.